PsS and Clemex

Particle & Surface Sciences Pty Limited  (PsS™) has been appointed Sole Distributor within Australia and New Zealand for Clemex Technologies Inc., a leading source of image analysis systems for quantitative microscopy, which provide detailed information of morphology, particle size, number and shape parameters. 

Clemex Technologies Inc. provides image analysis systems and image analysis software for quality control and research laboratories. Applications include manufacturing, pharmaceuticals, aerospace, automotive, and research.

Particle Size and Shape Image Analysis Workstation - Clemex PS3

The Clemex PS³ is an automated image analysis solution combining Clemex’s powerful particle characterization software, with an automated microscope and high resolution camera, all seamlessly integrated into an intuitive easy-to-use imaging workstation.

Addressing a need in the field of particle characterization, the Clemex PS³ is a versatile particle size and particle shape analysis tool that can be used in a wide range of applications in the pharmaceutical industries and material science.

Laboratory  Unit

The Lab Unit is a self-contained automated image analysis solution that combines Clemex's powerful particle characterization software with an automated microscope and high resolution camera. It is a turnkey solution for labs that want to maintain an analytical microscopy environment with minimum intervention by the operator yet still yield maximum detail in the results.

Research Unit

The Clemex PS3 Research Unit is a more traditional microscopy solution. It is a highly integrated system that combines image analysis software, up to two digital cameras (for example, color and monochrome), a microscope, a high performance PC, a motorized x/y/z stage, and has the flexibility of adjusting parameters (such as various light filters). This system has been designed to serve the scientist that must analyze various samples and, according to the best optical settings, develop methods of analysis for each one.

Image Analysis by Microscopy

Recently, the use of microscopy and image analysis is increasingly being recognized as the most reliable technique to characterize particle shape and characterize a particle size and volume distribution. Traditional methods, such as laser diffraction, although highly efficient, give limited information on particle shape proving image analysis as the best tool for performing particle analysis. 

Shape and Size Analysis

Industry experts, especially pharmaceutical, are now looking to characterize particle shape in addition to particle size, to gain a better understanding of how shape can effect the various properties of a product. More are recognizing the significance of particle size and shape as well as their impact on the physical characteristics of many particulate materials. Process problems with drug substances can often be attributed to the particle size or shape of the active material.
The ability to accurately analyze and characterize particle size and shape by image analysis can significantly improve your company’s manufacturing efficiency. It can also improve product performance for maximum effectiveness.

True Particles Shape

Clemex PS³ provides true particle shape information. Information is not determined by “correction factors” rather it is based on exactly what is seen in the microscope. Measurements are possible for individual or mixtures of different textured particles (opaque, semi-transparent, crystalline, etc).

Accuracy - Clemex PS³  

Clemex PS³ features excellent resolution and detection of micronized particles as small as 0.5 microns. Our unique automated calibration routine assures complete validation of measurement accuracy, in accordance with NIST standards. Particle volume determination is based on absolute 2D measurements and thus not limited to spheroids. Accurate volume measurements can be performed on elongated cylinders, acicular or irregular shaped objects.

Repeatability

Microscope parameters and camera settings are saved as properties in the routine associated with each sample. In conjunction with an automated workstation, an image analysis routine can be executed multiple times with no deviation from the initial results. This guarantees reproducibility and traceability of analysis, ensuring accurate results and conforming to 21 CFR Part 11 requirements.

High Throughput

Data collection is achieved through multiple field analysis using a Clemex 4-slide sample holder and motorized stage. Our robotic image analysis system will allow the user to measure large number of slides simultaneously without any operator intervention.

Results Management Clemex PS³

Clemex PS³ automatically calculates various measurements simultaneously on thousands of individual particles. It is capable of generating statistically significant results in an amazingly short time. The powerful report generator allows speedy data processing and flexible reporting capabilities.

Security and Compliance

Clemex PS³ allows the management of user rights, audit trail of critical interventions, electronic signatures as well as overwrite protection of all electronic documents produced by Clemex PS³ imaging workstation (images, stage patterns, image analysis routines, raw binary data, image analysis report in PDF). Traceability is assured by saving all analysis settings, data, results and images (if required) in the same protected file. All of these security features are designed to conform to regulatory requirements such as FDA 21 CFR part 11 ensuring data integrity.  

For more information on Clemex Products, please visit www.clemex.com